introduction
there are a number of diseases that have emerged in recent decades due to environmental disruption and overpopulation. the number of resistant species of bacteria is significant, and the diseases they cause are increasingly difficult to treat. though borrelia bacteria have been evident throughout the history of humanity, the severity of global disruption has increased their numbers and rates of infection, dramatically. regrettably, many healthcare practitioners are fearful of these diseases.
though often referred to as lyme disease, infections by borrelia bacteria are correctly referred to as borreliosis. before much was understood about the disease, lyme was used to describe a unique complex of symptoms that seemed to emerge in the mid twentieth century in a town called lyme, in connecticut, united states. it was the first time that bacteria had been discovered to cause arthritis. as time passed, it was thought that borrelia bacteria were causing many different diseases — arthritis, cardiovascular disease, neurological disorders, oncological diseases, but it eventually became clear that it was merely one disease.
borrelia bacteria can elicit a very diverse range of symptoms, which is one of the reasons that physicians uneducated misdiagnose patients with conditions ranging from multiple sclerosis to dementia. most physicians are not trained to recognise or treat borreliosis. if inappropriately treated, or left untreated entirely, multiple systemic dysfunction occurs, becoming chronic and debilitating. often patients are mistakenly diagnosed with a variety of psychiatric disorders such as bipolar disorder or schizophrenia because physicians either simply cannot believe that a patient has such a diverse range of seemingly unrelated symptoms — often strange symptoms the physician has never encountered, or the nervous system of the patient has so far degraded that the symptom pictures become identical.
misdiagnosis and iatrogenesis are very common, and psychiatric disorders are the ‘old reliable’ diagnoses, despite the fact that the vast majority of physicians have no education in the field of psychiatry. the general knowledge of most healthcare practitioners is quite limited, and most are inadequately qualified. the necessity of a holistic approach that considers constitution and other factors is not widely understood, which leads to tremendous suffering that is beyond the intent of the present article, but in the opinion of the author, constitutes malpractice. in truth, if a condition appears to be emotional, the ætiology is likely physical. and, conversely, if it appears to be physical, the ætiology is likely emotional.
borreliosis is caused by a particular phylum of gram negative bacteria called spirochaetota. spirochaetes are ancient, having lived for billions of years, and are integral to the function of the planet. they reside in a variety of habitats, including marine sediments and soils. they reside commensally in the gastrointestinal tracts of arthropoda, crustacea, and squamata. they can be pathogenic or nonpathogenic, parasitic or nonparasitic, and aerobic or anaerobic. borrelia bergdorferi is the spirochaete species most commonly associated with borreliosis, however there are many others. as borrelia bacteria paralyse multiple aspects of the immune system, most ‘coinfections’ are consequence of the borrelia infection, rather than simultaneously occurring coinfections. these consequential infections can be bacterial, viral, fungal, and parasitic, and include anaplasma, chlamydia, helminths, human alphaherpesvirus, mycoplasma and syphilis. the primary coinfections of borreliosis are members of the phylum pseudomonadota, which include, babesia, bartonella, campylobacter, ehrlichia, helicobacter, salmonella, and others. mould and fungi are always present in borrelia infection. these organisms share segments of deoxyribonucleic acid ( dna ) coded for resistance and virulence.
bacteria have a limited number of genes that typically range from six to fifteen. as borrelia infection rates progressed, it became evident that borrelia bacteria seemed to have a significant number more, which led to an interest in research. in the early twenty first century, researchers collected specimens from the eastern united states, and returned to deutschland to investigate. they discovered that the ‘borrelia like’ organisms that had been collected had more than six hundred genes. this exorbitant number led these researchers to suspect that there had been a genetically engineered organism created in a laboratory introduced to the environment. regardless of whether or not this particular suspicion is true, the fact that humanity is the cause of extreme environmental disruption is unequivocal. as a result, disease is rampant, and healthspan and lifespan are decreasing.
environmental disruption
there are tens of thousands of toxins in the environment, and all of them can be found in the body. though the body is highly intelligent, and capable of miraculous healing, the toxic burden has become too great, and many can no longer withstand the pressure. humans and their domesticated companions are so contaminated with these poisonous substances that pathogenic microbes more easily weaken the immune system, leading to disease and premature death. fluoride, heavy metals, organophosphates, plastics and dangerous electromagnetic microwave frequencies are some of the primary culprits.
the synergistic effects of these toxicants are worse still. organophosphates, such as atrazine and glyphosate, chelate minerals causing nutrient deficiency, eradicating the microbiome. these pesticides facilitate the absorption of heavy metals. without the presence of organophosphates, the intestinal epithelium would act as the effective barrier it is meant to be, preventing much of the absorption of toxins. but these pesticides are currently inescapable. even biological, organic foods contain as much as eighty percent of the amount that contaminates conventionally grown foods.
aluminium, which contaminates the air, food, and water supplies, is the most abundant heavy metal contaminating life. research conducted by internationally renowned physician, author, and researcher, dietrich klinghardt, indicated that patients had an average of ninety four times more aluminium in the bloodstream than any other heavy metal, including mercury. mercury, which contaminates the air, food, and water supplies, is a highly destructive heavy metal that is very damaging to the brain and the nervous system. but as it inhibits inflammation, some patients live without many warning signs or symptoms until the catastrophic end. this accounts for some of the jarisch herxheimer reaction that occurs when detoxification begins.
as the body has no effective biological barrier to protect the pulmonary vessels, the lungs are extremely vulnerable. inhalation of vapours and nanonised particles of heavy metals is particularly dangerous. furthermore, mould, mycotoxins, and fungi easily infest these highly susceptible organs, further weakening the patient. asthma and other respiratory diseases are very common, and the rate of pulmonary cancer has increased significantly, despite a dramatic decrease in nicotine consumption.
the negative effects of electromagnetic radiation have a major influence on the progression of disease. these microwave frequencies are highly immunosuppressive, and promulgate the replication and increased virulence of pathogenic microbes. research reveals a dramatic increase in the production of mould and mycotoxins exposed to wifi, and virulence has been shown to be increased by six hundred times. these frequencies very effectively weaken the immune system, thereby facilitating infection by borrelia, allowing the pathogens to flourish.
heavy metals, mould, and fungi protect pathogenic microbes in the blood vessels. borrelia bacteria inhabit the lining of blood vessels throughout the body. therefore, addressing metal toxicity and decreasing the toxic burden of fluoride, mould, organophosphates, other chemicals, and exposure to electromagnetic radiation removes some of the protective mechanisms utilised by borrelia bacteria, and will thereby greatly reduce their numbers in the body. this will also restore some cognitive function that has been dramatically diminished in the past several decades caused by these toxicants. intelligence is in such severe decline that there is a near total lack of attention span and a population obsessed with video games and social media, fully content to scroll mindlessly through inane content, such as the very peculiar ‘unboxing’ videos, that further contributes to a decline in health.
the immune response to borrelia bacteria is even more destructive than the pathogenic microbes, themselves. it is imperative to understand the behaviours of the bacteria in order to understand how to develop an effective protocol, which involves addressing the cytokine cascade, whilst considering the specific conditions of an individual’s immune system. environmental disruptions and trauma are the primary causal factors of epigenetic mutations. these genetic mutations are a determining factor for disease and its severity. trauma caused by abuse, divorce, famine, exposure to neurotoxins, injury, war, etc. causes changes in genetic expression that negatively affect the methylation of deoxyribonucleic acid ( dna ). these genetic mutations are inherited by offspring, affecting generations progressively.
all of these factors combined with egregious overpopulation are devastating this planet. those astute, understand fully that survival shall require leaving this planet behind if drastic change is not imminent. that is a fact so vulgar that it is difficult to contemplate — and for that reason, most never do. mundus vult decipi ( the world prefers to be deceived ) because truth is often too complex or too frightening to confront for many. the taste for objective truth is a taste that few acquire. however, facts do not cease to be true because they are ignored or unrecognised, and lessons unlearnt in this incarnation must be learnt in another.
prevalence of misconception
misconception and misinformation are abundant in medicine, and can be attributed to factors that include indoctrination and hypercapitalism. the fact that industry sponsored trials are permitted can only be described as outrageous. every aspect of medicine — clinical, education, and research — is profoundly influenced by the pharmaceutical and technological industries, and the cost — disease, death, and maltreatment — is enormous. until the practice of medical treatment for profit is discontinued, there shall be no legitimate healthcare.
there are many forms of bias in research, including conscious biases, such as data manipulation motivated by financial or political gain, and unconscious biases, such as complacent ignorance, poor quality clinical trial design, flawed execution, and orthodoxy resulting in psychological or emotional motivation. indeed, marcia angell, the former editor in chief of the new england medical journal, admitted that ‘bias is rampant’. she further stated, ‘trials can be rigged in a dozen ways, and it happens all the time. the most dramatic form of bias is complete suppression’. the majority of the public remain unaware of these inaccuracies, inadequacies, and injustices.
since evidence of borreliosis emerged, scientific studies have been utilised to promulgate a biased perspective. in the early days of its discovery, pioneer physicians including joseph burrascano and charles ray jones were treating patients with some significant success. however, copious research articles were published in an attempt to excoriate their efforts. that research is conducted, published, and peer reviewed is not inherent validation of its integrity. it is essential to understand the nuances of research in order to discern between fact and fiction. often research techniques do not fulfill the criteria necessary to exclude bias and precondition, which gravely jeopardises the authenticity of the results. much published research has resulted in a great deal of controversy and misconception that inhibits the understanding of borreliosis, and therefore appropriate treatment.
common misconceptions
one of the most glaring misconceptions regarding borrelia bacteria is that they are still primarily considered to be transmitted solely by ixodida ( ticks ). however, there are many modes of transmission. borrelia spirochaetes are present in a variety of arthropoda, including ants, fleas, flies, lice, mosquitoes, mites and spiders — essentially any biting or stinging arachnida or insecta, and crustacea and squamata, including lizards and snakes. use of the phrase, ‘tick borne illness’ is highly deceptive. in fact, transmission occurs far more frequently by fleas and mosquitoes.
direct animal to animal transmission is also very common. research demonstrates the prevalence of borrelia bacteria in a variety of mammalia. infection of chiroptera and rodentia are epidemic, and infection of bovinae, including cattle, and cervidae, including deer, elk, and moose are common. amongst humans, borrelia bacteria and many of its coinfections are transmitted to the foetus in utero. this transmission also results in mitochondrial dysfunction, oxidative stress, and neuroexcitoxicity that impairs foetal development that either directly results in or exacerbates the development of autism spectrum disorders later in life. borrelia bacteria are also present in animal lactation, saliva, semen and vaginal secretions, so entire families are often infected with identical genotypes. these spirochaetes immediately colonise the urinary bladder of anyone infected, and the bacteria pass live through the urine — a mechanism of survival and transmission. furthermore, borrelia bacteria and many of its coinfections are airborne. it warrants repeating that the phrase ‘tick borne illness’ is highly deceptive.
the widely accepted rate of transmission is another common misconception. though a transmission time of twenty four to forty eight hours is often stated by an uneducated medical community, and quoted by an inculcated and complacent public, transmission can occur within minutes. there are a number of factors that determine the rate of transmission, which include the species, subspecies, and strain of the spirochaetes inhabiting the vector, the vector species, the location of spirochaetes within the vector, the state of digestion occurring in the vector, the coinfections present in the vector, and the immune health of the animal host. borrelia spirochaetes remain viable for months or even years, and have been shown in multiple studies to survive freezing and thawing, still fully capable of infecting an organism. because of urination by wildlife and domesticated animals, these spirochaetes continuously cover the plants and soils, and can be transmitted by foraging, recreation, or any contact with the earth’s surface.
another concern is geographic limitation. borrelia bacteria are still widely considered to be geographically limited. however, these pathogens reside worldwide. they are endemic throughout europe and north america, asia, south america, africa, australia, new zealand, and both the arctic and antarctic regions. not acknowledged for many decades, this misinformation meant that any patient request for assessment outside of the regions considered to be within geographical boundaries were often dismissed. many patients were misdiagnosed and inappropriately treated, often with devastating consequences. still today, the majority of healthcare practitioners, including naturopathic practitioners, tell patients that they cannot possibly have borrelia infection unless residing or having travelled to particular regions.
there is tremendous misunderstanding regarding symptoms of borreliosis and its coinfections. the truth is that most individuals are carriers of the bacteria, some symptomatic and others not. an asymptomatic picture may or may not be disaster in waiting. symptoms and severity vary greatly, with epigenetics and history of trauma having a primary role. many asymptomatic individuals maintain a low level of infection in the body, until some form of significant stressor or trauma occurs at a later point in life that triggers an activation of the immune response. such stressors include exposure to neurotoxins and traumatic life experiences. as genetics determines an individual’s ability to cope with stress and trauma, that ability varies to a great degree. today, there is no one safe from exposure to neurotoxins, and stress is unavoidable. accumulative stress allows the infection to overcome the immune system, rendering it less efficient at containing the infection. trauma also provokes retroviral activity, dramatically increasing complications.
the early symptoms of infection most often resemble influenza virus. as the infection spreads, the symptoms begin to appear primarily in the joints, skin, and nervous system. though the appearance of erythema migrans, commonly referred to as a bull’s eye rash, is the most obvious definitive indication of infection, the majority of cases do not exhibit this symptom. the rash only occurs upon a secondary infection, id est, another bite or sting in an already infected individual. borrelia bacteria also invade any previously injured or impaired tissue. arthritis, chronic neck pain, fibromyalgia, thyroid dysfunction, temporomandibular joint disorder, sciatica, etc., may all be borrelia infection.
the diverse range of symptoms and the ineptitude of physicians generates a great deal of fear. however, it is not difficult to understand that it is the degradation of collagen and the immune response that are at the root of every symptom caused by borreliosis. borrelia bacteria have an affinity for collagenous tissue. symptoms occur at the feeding sites, in particular the joints, the heart, and the brain and nervous system. indeed, the majority of joint replacement surgeries, increasing at an alarming rate, are the result of borreliosis. and nerves are protected by a collagenous layer called myelin sheaths. these protective, insulating layers are destroyed once borrelia bacteria colonise. the nerves then begin to produce aberrations in neurological function, and neurogenic switching occurs. protecting and restoring the collagen structures of the body are critical components of both prevention and treatment.
an inflated faith in the effectiveness of pharmaceutical antibiotics is another concern. though pharmaceutical antibiotics may have a role in certain scenarios — often a very important one, the associated statistics are grossly exaggerated. many studies claim rates of effectiveness of seventy to ninety five percent. but not included in these studies are the relapse rates or the number of individuals who do not respond to pharmaceutical antibiotics at all. also ignored are the disastrous consequences of the use of these pharmaceuticals. life axiomatically has an instinct for self preservation, and bacteria are no different. upon attack, they develop defence mechanisms and evolve rapidly, making them exceedingly difficult to treat. these pharmaceuticals eradicate the microbiome, leading to nutrient deficiency and gastrointestinal dysfunction, further complicating the disease. ultimately, the approach of allopathic medicine results in a battle that is likely to be lost by the patient. the world’s leading medical experts treating borreliosis have an understanding that pharmaceutical antibiotics are not salubrious in the majority of cases.
minimum inhibitory concentration ( mic ) value should be considered in the treatment of any disease including borreliosis and coinfections. a remedy has a low mic value if it destroys a large percentage of microbes in low concentrations, and a remedy has a high mic value if it destroys a small percentage of microbes in high concentrations. pharmaceutical antibiotics have a low mic value for all microbes, meaning they do not selectively destroy pathogenic bacteria, but rather broad groups of diverse bacteria. effective treatment consists of utilising compounds that have a low mic value for pathogenic microbes, but a high mic value for bacteria that constitute a healthy microbiome.
the profligate use of these drugs and the ecological disruption caused by an increasing human population density are the primary impetuses of the emergence of very potent and very resistant bacteria. the planet has been inundated with hundreds of millions of tonnes of non biodegradable pharmaceutical substances created to eradicate bacteria, which has catapulted unparalleled biological and evolutionary changes. due to the importance of bacteria to the ecological functioning of the planet, these organisms had no choice but to evolve resistance. otherwise, all life would be eradicated by pharmaceutical antibiotics. overcoming hubris by accepting the limitations of pharmaceutical antibiotics is critical.
though acupuncture is a beautiful therapy capable of treating a variety of conditions, there is one major caveat. acupuncturists spend a great deal of time learning hundreds of acupuncture points, but what most fail to understand is that those points are only accurate in a sufficiently healthy organism that adequately emits coherent light. once a certain level of dysfunction is reached, these points migrate. it is imperative to understand biophysics in order to provide effective acupuncture treatments.
the use of insecticides and chemical repellants contributes to both disease and environmental disruption. multiple studies have demonstrated the many dangers associated with such chemicals. the belief that oral and topical medications for domesticated companion species are effective or safe is deeply concerning. well intentioned — albeit uninquisitive — guardians who have a tendency to simply believe what they are told by those considered to be authorities are unwittingly poisoning their companions — and themselves and other family members — with these extremely dangerous chemical compounds. these toxicants are hazardous and entirely unnecessary. they do not repel fleas and ticks. but they do cause endocrine and gastrointestinal dysfunction, and devastating neurological effects, including seizures and paralysis. thousands of canines and felines die as a direct result of exposure to these medications. botanical remedies are not only the safest, but the most effective mode of prevention and treatment.
lastly, there is a great deal of misconception regarding diagnosis. the commonly available diagnostic testing for borreliosis remains inadequate and ineffective. enzyme linked immunosorbent assay ( elisa ) and western immunoblot measure antibodies in the blood. however, the production of antibodies is greatly compromised in borrelia infected patients, which renders it senseless to depend upon these tests for accurate diagnosis. if a patient were treated with an appropriate and effective protocol, and recovered enough to resume adequate production of antibodies, only then could an accurate positive result be obtained. furthermore, these tests are only capable of validating the presence of particular spirochaete species, despite the fact that there are dozens of species, subspecies, and strains.
polymerase chain reaction ( pcr ) tests amplify levels of deoxyribonucleic acid ( dna ) of spirochaetes to elicit perception for analysis. however, spirochaetes are not present in homogeneous tissue, which means limited numbers are likely to be detected. and as pharmaceutical antibiotics further inhibit detection of spirochaetes, these tests are not effective if a protocol consisting of these drugs has been used.
importantly, borrelia bacteria utilise biofilms that are capable of shielding the pathogens from any detection. an estimated seventy percent of cases are left undetected in the early stage of infection, and patients are only retested after their health significantly deteriorates. a negative result obtained by any of these tests cannot prove the absence of infection. definitive diagnosis is achieved with a sequence that includes assessment of direct resonance and biochemical parameters obtained from a more sophisticated laboratory.
though it may be ignorance that inhibits successful treatment of patients by the physicians who possess integrity, it is important to remain cognisant of the more sinister causal factors. there are many unscrupulous practitioners who have no genuine interest in healing patients. it is, after all, diseased individuals who must pay to consult with physicians in perpetuity, not healthy ones. such physicians are financially compensated by pharmaceutical and technological companies, and these compensations heavily influence clinical decisions and prescriptions. as for the conscionable practitioners who are well cognisant of the faults of conventional medicine, the pressure to prescribe pharmaceutical drugs causes ethical dilemmas and tremendous stress. indeed, the rates of suicide within the medical community are nearly twice as high as those of the general population.
conclusion
indeed, borreliosis and its coinfections are complicated and complex, and treatment is highly nuanced, but it is possible to heal from these infectious diseases. this requires a holistic and multidimensional approach that includes accurate diagnosis, regulation of physiology and biochemistry, modulation of the immune system, detoxification, nutritional support, a protocol consisting of appropriate botanical therapies, and a bit of compassion. eventually, borreliosis can resemble any known disease, and often mimics and exacerbates any existing physical, psychological or psychiatric condition. the severity of symptoms correlates with the toxic burden, the overall summation of coexisting conditions, and with the genetically determined ability to excrete neurotoxins. metabolic dysfunction, particularly in methylation, acetylation, and sulfation pathways, is another correlation. other factors, such as diet, food allergies, physical, emotional, psychological, and ancestral trauma, interference fields such as scar tissue and tattoos, and structural concerns with the vertebral column and dental occlusion are also very important.
antiquated paradigms learnt in medical school severely impact the successful treatment of these diseases — and medicine as a whole. these beliefs reside deeply within the psyche of the vast majority of practitioners, including naturopathic physicians. practitioners remain so indoctrinated by paradigms that they are guided by theory, rather than by observation. but the flaws have been long evident to the discerning. for the others, change can be very difficult. physicians are not immune to cognitive dissonance. it can be extremely uncomfortable to realise that beliefs long held may not be true. but it is imperative to overcome this challenge. those willing to exercise humility shall begin to see greater success in practice, and truly help patients to heal.
borrelia bacteria have inhabited this planet far longer than mammals. they are not an enemy. it is humanity that is the enemy. the environment is so severely altered that imbalance is nearly irreversible. when the planet’s microbiome is weakened, more highly evolved species are weakened, allowing pathogens to proliferate. these lesser evolved species have proliferated to such a degree that life is endangered, and is leading to extinction. borreliosis is a warning. if drastic changes are not made, the next mass extinction is inevitable.
REFERENCES
Antonucci, Nicola & Klinghardt, Dietrich & Pacini, Stefania & Ruggiero, Marco. (2018). Tailoring the Ruggiero-Klinghardt Protocol to Immunotherapy of Autism. American Journal of Immunology. 14. 34-41. 10.3844/ajisp.2018.34.41.
Asman, M, M Nowak, P Cuber, et al. “The risk of exposure to Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Babesia sp. and coinfections in Ixodes ricinus ticks on the territory of Niepolomice forest (southern Poland).” Annals of Parasitology 59, no. 1 (2013): 13–19.
Bai, Ying & Cross, Paul & Malania, Lile & Kosoy, Michael. (2010). Isolation of Bartonella capreoli from elk. Veterinary microbiology. 148. 329-32. 10.1016/j.vetmic.2010.09.022.
Bai, Ying & Calisher, Charles & Kosoy, Michael & Root, J & Doty, Jeffrey. (2011). Persistent Infection or Successive Reinfection of Deer Mice with Bartonella vinsonii subsp. arupensis. Applied and environmental microbiology. 77. 1728-31. 10.1128/AEM.02203-10.
Bai, Ying & Malania, Lile & Alvarez, Danilo & Moran, David & Boonmar, Sumalee & Chanlun, Aran & Suksawat, Fanan & Maruyama, Soichi & Knobel, Darryn & Kosoy, Michael. (2013). Global Distribution of Bartonella Infections in Domestic Bovine and Characterization of Bartonella bovis Strains Using Multi-Locus Sequence Typing. PloS one. 8. e80894. 10.1371/journal.pone.0080894.
Barber RM, Li Q, Diniz PP, Porter BF, Breitschwerdt EB, Claiborne MK, Birkenheuer AJ, Levine JM, Levine GJ, Chandler K, Kenny P, Nghiem P, Wei S, Greene CE, Kent M, Platt SR, Greer K, Schatzberg SJ. Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases). J Vet Intern Med. 2010 Mar-Apr;24(2):372-8. doi: 10.1111/j.1939-1676.2009.0466.x. PMID: 20102497.
Battsetseg B, Matsuo T, Xuan X, Boldbaatar D, Chee SH, Umemiya R, Sakaguchi T, Hatta T, Zhou J, Verdida AR, Taylor D, Fujisaki K. Babesia parasites develop and are transmitted by the non-vector soft tick Ornithodoros moubata (Acari: Argasidae). Parasitology. 2007 Jan;134(Pt 1):1-8. doi: 10.1017/S0031182006000916. Epub 2006 Sep 18. PMID: 16978440.
Bergen DC, Silberberg D. Nervous system disorders: a global epidemic. Arch Neurol. 2002 Jul;59(7):1194-6. doi: 10.1001/archneur.59.7.1194. PMID: 12117370.
Blair JM, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJ. Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol. 2015 Jan;13(1):42-51. doi: 10.1038/nrmicro3380. Epub 2014 Dec 1. PMID: 25435309.
Bransfield RC, Wulfman JS, Harvey WT, Usman AI. The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders. Med Hypotheses. 2008;70(5):967-74. doi: 10.1016/j.mehy.2007.09.006. Epub 2007 Nov 5. PMID: 17980971.
Breitschwerdt EB, Maggi RG, Duncan AW, Nicholson WL, Hegarty BC, Woods CW. Bartonella species in blood of immunocompetent persons with animal and arthropod contact. Emerg Infect Dis. 2007 Jun;13(6):938-41. doi: 10.3201/eid1306.061337. PMID: 17553243; PMCID: PMC2792845.
Breitschwerdt EB, Maggi RG. A confusing case of canine vector-borne disease: clinical signs and progression in a dog co-infected with Ehrlichia canis and Bartonella vinsonii ssp. berkhoffii. Parasites & Vectors. 2009 Mar;2 Suppl 1:S3. DOI: 10.1186/1756-3305-2-s1-s3. PMID: 19426442; PMCID: PMC2679395.
Breitschwerdt EB, Maggi RG, Farmer P, Mascarelli PE. Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and Bartonella henselae to a child. J Clin Microbiol. 2010 Jun;48(6):2289-93. doi: 10.1128/JCM.00326-10. Epub 2010 Apr 14. PMID: 20392912; PMCID: PMC2884525.
Bork S, Das S, Okubo K, Yokoyama N, Igarashi I. Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis. Parasitology. 2006 Jun;132(Pt 6):775-9. doi: 10.1017/S0031182006009917. Epub 2006 Feb 24. PMID: 16497251.
Brown WC, Suarez CE, Shoda LK, Estes DM. Modulation of host immune responses by protozoal DNA. Vet Immunol Immunopathol. 1999 Dec 15;72(1-2):87-94. doi: 10.1016/s0165-2427(99)00120-8. PMID: 10614497.
Chauvin A, Moreau E, Bonnet S, Plantard O, Malandrin L. Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission. Vet Res. 2009 Mar-Apr;40(2):37. doi: 10.1051/vetres/2009020. Epub 2009 Apr 21. PMID: 19379662; PMCID: PMC2695028.
Chomel BB, Boulouis HJ, Breitschwerdt EB, Kasten RW, Vayssier-Taussat M, Birtles RJ, Koehler JE, Dehio C. Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors. Vet Res. 2009 Mar-Apr;40(2):29. doi: 10.1051/vetres/2009011. Epub 2009 Mar 14. PMID: 19284965; PMCID: PMC2695021.
Delaney, Shannon & Robveille, Cynthia & Maggi, Ricardo & Lashnits, Erin & Kingston, Emily & Liedig, Chance & Murray, Lilly & Fallon, Brian & Breitschwerdt, Edward. (2024). Bartonella species bacteremia in association with adult psychosis. Frontiers in Psychiatry. 15. 10.3389/fpsyt.2024.1388442.
Duarte D, El-Hagrassy MM, Couto TCE, Gurgel W, Fregni F, Correa H. Male and Female Physician Suicidality: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2020 Jun 1;77(6):587-597. doi: 10.1001/jamapsychiatry.2020.0011. PMID: 32129813; PMCID: PMC7057173.
Duncan AW, Maggi RG, Breitschwerdt EB. Bartonella DNA in dog saliva. Emerg Infect Dis. 2007 Dec;13(12):1948-50. doi: 10.3201/eid1312.070653. PMID: 18258056; PMCID: PMC2876763.
Erol, Erdal & Jackson, Carney & Bai, Ying & Sells, Stephen & Locke, Steve & Kosoy, Michael. (2013). Bartonella bovis isolated from a cow with endocarditis. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 25. 288-90. 10.1177/1040638713477408.
Johansson O. Disturbance of the immune system by electromagnetic fields-A potentially underlying cause for cellular damage and tissue repair reduction which could lead to disease and impairment. Pathophysiology. 2009 Aug;16(2-3):157-77. doi: 10.1016/j.pathophys.2009.03.004. Epub 2009 Apr 23. PMID: 19398310.
Klinghardt, Dietrich & Ruggiero, Marco. (2017). The Ruggiero-Klinghardt (RK) Protocol for the Diagnosis and Treatment of Chronic Conditions with Particular Focus on Lyme Disease. American Journal of Immunology. 13. 114-126. 10.3844/ajisp.2017.114.126.
Krueger, Laura & Bai, Ying & Bennett, Steve & Fogarty, Carrie & Sun, Sokanary & Kosoy, Michael & Maina, Alice & Nelson, Kimberly & Platzer, Edward & Osikowicz, Lynn & Allen, L. & Shariar, Farshid & Trinidad, Albert & Cummings, Albert & Cummings, Robert. (2016). Identification of Zoonotic and Vector-borne Infectious Agents Associated with Opossums (Didelphis virginiana) in Residential Neighborhoods of Orange County, California. Proceedings of the Vertebrate Pest Conference. 27. 10.5070/V427110386.
Lantos PM, Maggi RG, Ferguson B, et al. Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard? Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2014 Aug;14(8):563-570. DOI: 10.1089/vbz.2013.1512. PMID: 25072986; PMCID: PMC4117269.
Park MK, Park JS, Cho ML, Oh HJ, Heo YJ, Woo YJ, Heo YM, Park MJ, Park HS, Park SH, Kim HY, Min JK. Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol Lett. 2011 Mar 30;135(1-2):50-8. doi: 10.1016/j.imlet.2010.09.011. Epub 2010 Oct 7. PMID: 20933009.
Pritchard C, Rosenorn-Lanng E. Neurological deaths of American adults (55-74) and the over 75’s by sex compared with 20 Western countries 1989-2010: Cause for concern. Surg Neurol Int. 2015 Jul 23;6:123. doi: 10.4103/2152-7806.161420. PMID: 26290774; PMCID: PMC4521226.
Resto-Ruiz S, Burgess A, Anderson BE. The role of the host immune response in pathogenesis of Bartonella henselae. DNA Cell Biol. 2003 Jun;22(6):431-40. doi: 10.1089/104454903767650694. PMID: 12906736.
Saul, AW Medline bias. Townsend Letter for Doctors and Patients 277/278 (AugSep 2006): 122– 123. Editorial
Saul AW NLM censors nutritional research: Medline is biased, and taxpayers pay for it. Orthomolecular Medicine News Service (Jan 15, 2010).
Song SH, Wang ZZ. Analysis of essential oils from different organs of Scutellaria baicalensis. Zhong Yao Cai. 2010 Aug;33(8):1265-70. PMID: 21213540.
Schaller JL, Burkland GA, Langhoff PJ. Do bartonella infections cause agitation, panic disorder, and treatment-resistant depression? MedGenMed. 2007 Sep 13;9(3):54. PMID: 18092060; PMCID: PMC2100128.
Sudjana AN, D’Orazio C, Ryan V, Rasool N, Ng J, Islam N, Riley TV, Hammer KA. Antimicrobial activity of commercial Olea europaea (olive) leaf extract. Int J Antimicrob Agents. 2009 May;33(5):461-3. doi: 10.1016/j.ijantimicag.2008.10.026. Epub 2009 Jan 9. PMID: 19135874.
Van Bruggen AHC, He MM, Shin K, Mai V, Jeong KC, Finckh MR, Morris JG Jr. Environmental and health effects of the herbicide glyphosate. Sci Total Environ. 2018 Mar;616-617:255-268. doi: 10.1016/j.scitotenv.2017.10.309. Epub 2017 Nov 5. PMID: 29117584.
Wright GD. Molecular mechanisms of antibiotic resistance. Chem Commun (Camb). 2011 Apr 14;47(14):4055-61. doi: 10.1039/c0cc05111j. Epub 2011 Feb 1. PMID: 21286630.
Xu Q, Hao X, Yang Q, Si L. Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase. Biochem Biophys Res Commun. 2009 Oct 16;388(2):389-94. doi: 10.1016/j.bbrc.2009.08.021. Epub 2009 Aug 8. PMID: 19666001.